• David Price, Linda Kemp, Erika Sims, Julie von Ziegenweidt, Prakash Navaratnam, Amanda J Lee, Alison Chisholm, Elizabeth V Hillyer, and Gokul Gopalan.
• Academic Centre of Primary Care, University of Aberdeen, Aberdeen, UK. david@respiratoryresearch.org
• Prim Care Respir J. 2010 Sep 1; 19 (3): 266-73.

AimsRetrospective database study comparing upper and lower airway-related outcomes for patients with rhinitis and co-morbid asthma receiving mometasone furoate--an intranasal corticosteroid with low systemic bioavailability--or an oral antihistamine.Methods395 patients prescribed intranasal mometasone were matched on 10 demographic and respiratory-related criteria in a 1:2 ratio to 790 patients prescribed oral antihistamine. Asthma and rhinitis control were assessed over one year using predefined composite proxy measures.ResultsAsthma control was achieved by 309/395 (78.2%) versus 580/790 (73.4%; p=0.071) patients in the mometasone and antihistamine cohorts, respectively. Rhinitis control was achieved by 293 (74.2%) versus 539 (68.2%; p=0.035), respectively. The adjusted odds ratios for antihistamines, relative to mometasone, were 0.71 (95% CI, 0.52-0.98) for achieving asthma control and 0.74 (95% CI, 0.56-0.97) for achieving rhinitis control.ConclusionsPatients with rhinitis and co-morbid asthma initiating rhinitis therapy achieved significantly better upper as well as lower airway outcomes with intranasal mometasone than with oral antihistamine.

37 keywords...

hide…