• Javier Briceño, Alvaro Naranjo, Ruben Ciria, Rafael Díaz-Nieto, Juan-Manuel Sánchez-Hidalgo, Antonio Luque, Sebastián Rufián, and Pedro López-Cillero.
• Unit of Hepatobiliary Surgery and Liver Transplantation, Department of General Surgery, University Hospital Reina Sofía, Córdoba, Spain.
• Arch Surg. 2010 May 1; 145 (5): 482-8.

ObjectiveTo examine the effectiveness of fibrin sealants as supportive treatment to improve hemostasis and decrease the incidence of bile leakage and intra-abdominal collections.DesignProspective, controlled, quasiexperimental study.SettingTertiary referral center, University Hospital Reina Sofía.PatientsA total of 115 patients (58 in the control group and 57 in the collagen sponge group) scheduled for conventional hepatectomies.InterventionsPatients were distributed into groups for major and minor hepatectomies with or without application of a carrier-bound collagen sponge on the raw surface of the liver.Main Outcome MeasuresThe main outcome measures were postoperative mortality, incidence and severity of postoperative surgical complications, and length of hospital stay. The secondary outcome measures were postoperative drainage output volume, transfusion requirements, and changes in biochemical parameters (hemoglobin, bilirubin, alanine aminotransferase, and platelet levels).ResultsThe fibrin sealant after major liver resection was effective for decreasing drainage volume (mean [SD] volume, 1124.7 [842.8] mL in the control group and 691.2 [499.5] mL in the collagen sponge group; P = .007) with a higher volume of output by drain each postoperative day in the control patients (P = .003); postoperative blood transfusion requirements (18.9% vs 7.0%, respectively; P = .04); moderate to severe postoperative complications (21% vs 8%, respectively; P = .03); and mean (SD) hospital stay (12.6 [6.7] vs 9.6 [5.1] days, respectively; P = .03).ConclusionThe use of a new carrier-bound collagen sponge after major liver resection may be recommended because of its clinical and cost-savings effectiveness.

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