• Cardiology clinics · Nov 2014

    Review

    Antithrombotic and anticoagulant therapy for atrial fibrillation.

    • Mikhail S Dzeshka and Gregory Y H Lip.
    • University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH, UK; Grodno State Medical University, Grodno, Belarus.
    • Cardiol Clin. 2014 Nov 1; 32 (4): 585-99.

    AbstractAs atrial fibrillation (AF) substantially increases the risk of stroke and other thromboembolic events, most AF patients require appropriate antithrombotic prophylaxis. Oral anticoagulation (OAC) with either dose-adjusted vitamin K antagonists (VKAs) (eg, warfarin) or non-VKA oral anticoagulants (eg, dabigatran, apixaban, rivaroxaban) can be used for this purpose unless contraindicated. Therefore, risk assessment of stroke and bleeding is an obligatory part of AF management, and risk has to be weighed individually. Antiplatelet drugs (eg, aspirin and clopidogrel) are inferior to OAC, both alone and in combination, with a comparable risk of bleeding events.Copyright © 2014 Elsevier Inc. All rights reserved.

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