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- C T Bauch, Arni S R Srinivasa Rao, B Z Pham, M Krahn, V Gilca, B Duval, M H Chen, and A C Tricco.
- Department of Mathematics and Statistics, University of Guelph, Canada. cbauch@uoguelph.ca
- Vaccine. 2007 Feb 26; 25 (10): 1719-26.
AbstractVaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52, 36, 31%) and mortality attributable to HAV by 56% (respectively 45, 26, 25%), relative to continued targeted vaccination, over 80 years.
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