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Journal of neurology · May 2006
Comparative StudyDexamethasone and prognostic factors in adults with bacterial meningitis.
- Martijn Weisfelt, Diederik van de Beek, Rob J de Haan, and Jan de Gans.
- Department of Neurology, Academic Medical Center, 22660, 1100 DD, Amsterdam, The Netherlands. M.weisfelt@amc.uva.nl
- J. Neurol. 2006 May 1; 253 (5): 570-3.
ObjectiveTo determine the effect of dexamethasone on prognostic factors in adults with bacterial meningitis.Design And SettingA post hoc multivariate analysis of the European Dexamethasone Study.Patients And ParticipantsDexamethasone-treated patients in the European Dexamethasone Study. As internal validation we performed an identical analysis on patients in the placebo group.Measurements And ResultsOnly focal cerebral abnormalities on admission were predictive for unfavourable outcome in patients treated with early adjunctive dexamethasone (Odds ratio 3.22; 95% confidence interval 1.11-9.35; P=0.03). Other potential prognostic factors failed to achieve statistical significance. An analysis on patients in the placebo group showed prognostic factors comparable with those found in the literature without routine use of dexamethasone.ConclusionsRoutine use of dexamethasone therapy may lead towards new risk stratification in adults with bacterial meningitis.
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