Deep brain stimulation for chronic pain: intracranial targets,

Neurosurg. Clin. N. Am. · Oct 2014

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Deep brain stimulation for chronic pain: intracranial targets, clinical outcomes, and trial design considerations.

For over half a century, neurosurgeons have attempted to treat pain from a diversity of causes using acute and chronic intracranial stimulation. Targets of stimulation have included the sensory thalamus, periventricular and periaqueductal gray, the septum, the internal capsule, the motor cortex, posterior hypothalamus, and more recently, the anterior cingulate cortex. The current work focuses on presenting and evaluating the evidence for the efficacy of these targets in a historical context while also highlighting the major challenges to having a double-blind placebo-controlled clinical trial. Considerations for pain research in general and use of intracranial targets specifically are included.

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- Orion Paul Keifer, Jonathan P Riley, and Nicholas M Boulis.
- MD/PhD Program, School of Medicine, Emory University, Suite 375-B, 1648 Pierce Drive, Atlanta, GA 30322, USA.
- Neurosurg. Clin. N. Am. 2014 Oct 1; 25 (4): 671-92.
AbstractFor over half a century, neurosurgeons have attempted to treat pain from a diversity of causes using acute and chronic intracranial stimulation. Targets of stimulation have included the sensory thalamus, periventricular and periaqueductal gray, the septum, the internal capsule, the motor cortex, posterior hypothalamus, and more recently, the anterior cingulate cortex. The current work focuses on presenting and evaluating the evidence for the efficacy of these targets in a historical context while also highlighting the major challenges to having a double-blind placebo-controlled clinical trial. Considerations for pain research in general and use of intracranial targets specifically are included.Copyright © 2014 Elsevier Inc. All rights reserved.

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Deep brain stimulation for chronic pain: intracranial targets, clinical outcomes, and trial design considerations.

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