• Eur J Emerg Med · Dec 2006

    Case Reports

    Paradoxical reaction to epinephrine induced by beta-blockers in an anaphylactic shock induced by penicillin.

    • Nathalie-Sybille Goddet, Alexis Descatha, Oliver Liberge, François Dolveck, Jérémie Boutet, Michel Baer, Dominique Fletcher, and François Templier.
    • SAMU 92-SMUR Garches bOccupational Health Department, Raymond Poincaré teaching hospital, AP-HP, Garches, France. sybille.goddet@rpc.aphp.fr
    • Eur J Emerg Med. 2006 Dec 1; 13 (6): 358-60.

    AbstractIncreased risk of severe and resistant anaphylactic shock is a rare and not widely known adverse effect of beta-blocker treatment. It is illustrated in a case of refractory anaphylactic shock occurring in a 47-year-old woman who received beta-blockers. Actually, beta-blockers increase the release of anaphylactic mediators, decrease the cardiovascular compensatory changes to the anaphylactic shock and promote paradoxical reflex vagotonic effects when using epinephrine.

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