• V Hopwood, G Lewith, P Prescott, and M J Campbell.
• University of Southampton, Complementary Medicine Research Unit, Primary Medical Care, Aldermoor Health Centre, Aldermoor Close, Southampton, SO16 5ST, UK. val.hopwoodaacp@btinternet.com
• J. Neurol. 2008 Jun 1; 255 (6): 858-66.

ObjectiveTo investigate the efficacy of acupuncture on stroke recovery compared to an inert placebo.DesignPlacebo-controlled, randomised, clinical trial.SettingPost-stroke rehabilitation wards in five NHS hospitals in the UK.SubjectsPatients between 4 and 10 days after their first stroke.Interventions And Outcome MeasuresThe patients received 12 acupuncture or placebo treatments over four weeks. Acupuncture with electrical stimulation was compared with mock TENS, and assessments continued for 12 months after entry. Primary outcome was the Barthel Index (BI). Secondary outcomes were muscle power, Motricity Index (MI), mood, Nottingham Health Profile (NHP) and treatment credibility.Results92 patients completed data sets. Data were analysed using both t tests and a structural equation based on longitudinal analysis of both BI and MI, using generalised estimating equations with an exchangeable correlation structure. While both acupuncture and placebo (mock TENS) appeared to have had an equal effect on stroke recovery, there is no significant difference between the two interventions at 12 (p = 0.737, 95 % CI -2.00 to 2.81) and 52 weeks (p = 0.371, 95 % CI -3.48 to 1.32). An apparently accelerated improvement in the MI scores in the acupuncture group at 3 weeks (p = 0.009, 95 % CI 1.55 to 10.77) is interesting.ConclusionsAcupuncture did not demonstrate specific efficacy over placebo and both groups did as well as normally expected with this condition.

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