• Hyoung Jun Kim, Tae Oh Kim, Bong Chul Shin, Jae Gon Woo, Eun Hee Seo, Hee Rin Joo, Nae-Yun Heo, Jongha Park, Seung Ha Park, Sung Yeon Yang, Young Soo Moon, Jin-Yong Shin, and Nae Young Lee.
• Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. kto044@paik.ac.kr
• Digestion. 2012 Jan 1; 86 (3): 194-200.

Background/AimsCurrently, a split-dose of polyethylene glycol (PEG) is the mainstay of bowel preparation due to its tolerability, bowel-cleansing action, and safety. However, bowel preparation with PEG is suboptimal because residual fluid reduces the polyp detection rate and requires a more thorough colon inspection. The aim of our study was to demonstrate the efficacy of a sufficient dose of prokinetics on bowel cleansing together with split-dose PEG.MethodsA prospective endoscopist-blinded study was conducted. Patients were randomly allocated to two groups: prokinetic with split-dose PEG or split-dose PEG alone. A prokinetic [100 mg itopride (Itomed)], was administered twice simultaneously with each split-dose of PEG. Bowel-cleansing efficacy was measured by endoscopists using the Ottawa scale and the segmental fluidity scale score. Each participant completed a bowel preparation survey. Mean scores from the Ottawa scale, segmental fluid scale, and rate of poor preparation were compared between both groups.ResultsPatients in the prokinetics with split-dose PEG group showed significantly lower total Ottawa and segmental fluid scores compared with patients in the split-dose of PEG alone group.ConclusionA sufficient dose of prokinetics with a split-dose of PEG showed efficacy in bowel cleansing for morning colonoscopy, largely due to the reduction in colonic fluid.Copyright © 2012 S. Karger AG, Basel.

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