• Delphine Borgel and Antoine Vieillard-Baron.
• AP-HP, Service d'Hématologie et d'Immunologie, Hôpital Ambroise Paré, 9 av Charles de Gaulle, 92100 Boulogne Billancourt - EA4531, Faculté de Pharmacie, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Chatenay-Malabry, France. delphine.borgel@apr.aphp.fr
• Med Sci (Paris). 2011 May 1; 27 (5): 501-7.

AbstractSepsis is defined as a systemic response to infection, characterized by an intense inflammatory response linked to coagulation activation and fibrinolysis inhibition, two processes which are intimately associated. In a field where mortality remains very high, administration of activated protein C, a physiological coagulation inhibitor with cytoprotective properties, has demonstrated its effectiveness and was able to reduce mortality. Protein C belongs to a system that involves plasma proteins and endothelial cell receptors. In addition to well documented effects on coagulation and fibrinolysis, activated protein C exhibits anti-inflammatory, anti-apoptotic but also anti-histone activities. Indeed, a recent study focusing on the cytoprotective effects of activated protein C showed that extracellular histones are released during severe sepsis and may participate in the pathophysiology of severe sepsis. These histones appear to be new targets of activated protein C.© 2011 médecine/sciences - Inserm / SRMS.

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