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- Sun Kwang Kim, Byung-Il Min, Ji Hoon Kim, Byung Gil Hwang, Gi Yong Yoo, Dong Suk Park, and Heung Sik Na.
- Department of East-West Medicine, Graduate School, Kyung-Hee University, Seoul, South Korea.
- Eur. J. Pharmacol. 2005 Oct 31; 523 (1-3): 64-6.
AbstractIn neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia.
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