• Mater Med Pol · Oct 1991

    Comparative Study

    Effect of mannitol on intracranial pressure in focal cerebral ischemia. An experimental study in a rat.

    • Z Kotwica and L Persson.
    • Department of Neurosurgery, Medical Academy, Lódź, Poland.
    • Mater Med Pol. 1991 Oct 1; 23 (4): 280-4.

    AbstractThe authors studied the effects of mannitol on intracranial pressure (ICP) in experimental focal ischemia in a rat. Stroke was produced by occlusion of middle cerebral artery (MCA). The study revealed that mannitol decreases ICP in ischemic stroke much less then in healthy animals and also a significant rebound effect was seen, especially in the 5th and 7th day after MCA occlusion. The authors suggest a very limited use of mannitol in clinical treatment of elevated ICP after cerebral ischemic stroke.

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