• Critical care clinics · Oct 2003

    Acute lung injury and the acute respiratory distress syndrome.

    • Ivan W Cheng and Michael A Matthay.
    • University of California, San Francisco, Cardiovascular Research Institute, 505 Parnassus Avenue, Box 0130, San Francisco, CA 94143-0624, USA. icheng@itsa.ucsf.edu
    • Crit Care Clin. 2003 Oct 1; 19 (4): 693-712.

    AbstractAlthough ALI/ARDS mortality rates have improved over the last several decades, they remain high, particularly in the geriatric patient population. Although considerable progress has been made in understanding the pathogenesis of the disease, a large number of promising treatments have proven unsuccessful. One exception has been in the area of ventilator management, where a strategy of protective ventilation with low tidal volumes has demonstrated a significant mortality benefit. Basic research continues to help advance our understanding of this complex syndrome and identify interesting new directions of investigation. The results of several large, randomized trials of new ventilatory and pharmacologic strategies currently underway may help identify successful methods of treating this important disease.

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