• Michelle Buehner, Jeremy Pamplin, Lynette Studer, Rhome L Hughes, Booker T King, John C Graybill, and Kevin K Chung.
• From the *Department of Surgery, San Antonio Military Medical Center, Fort Sam Houston, Texas; †U.S. Army Institute of Surgical Research, JBSA, ‡Department of Pathology, San Antonio Military Medical Center, Fort Sam Houston, Texas; and §Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
• J Burn Care Res. 2016 Jul 1; 37 (4): e374-9.

AbstractFluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients. To the best of our knowledge, the authors present the first case series in burn patients in whom calcium oxalate nephropathy has been identified after high-dose vitamin C therapy.

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