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Revue médicale suisse · Jun 2011
Case Reports[Analgesic placebo effect: contribution of the neurosciences].
- C Berna, Y Cojan, P Vuilleumier, and J Desmeules.
- Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, UK. cberna@fmrib.ox.ac.uk
- Rev Med Suisse. 2011 Jun 29; 7 (301): 1390-3.
AbstractOver the past twenty years, neuroscience has changed our understanding of placebo analgesia. Often perceived by researchers as a response bias adding noise to the assessment of efficacy, in the patients' view, it is associated with charlatanism. The origin of the word, qualifying a patient's response to "please" the doctor, did not help its rightful appreciation. However, today the placebo analgesia is considered as a psychobiological phenomenon. Thanks to pharmacological manipulations and the development of functional brain imaging, the neural circuitry involved in this effect as well as the role of endorphins and dopamine have been identified. This article describes our current knowledge about this fascinating phenomenon: a psychological modulation can lead to a biological effect.
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