• Sophia E de Rooij, Ameen Abu-Hanna, Marcel Levi, and Evert de Jonge.
• Department of Geriatrics, Academic Medical Center, University of Amsterdam, Amsterdam. s.e.derooij@amc.uva.nl
• Crit Care. 2005 Aug 1; 9 (4): R307-14.

IntroductionAdvanced age is thought to be associated with increased mortality in critically ill patients. This report reviews available data on factors that determine outcome, on the value of prognostic models, and on preferences regarding life-sustaining treatments in (very) elderly intensive care unit (ICU) patients.MethodsWe searched the Medline database (January 1966 to January 2005) for English language articles. Selected articles were cross-checked for other relevant publications.ResultsMortality rates are higher in elderly ICU patients than in younger patients. However, it is not age per se but associated factors, such as severity of illness and premorbid functional status, that appear to be responsible for the poorer prognosis. Patients' preferences regarding life-sustaining treatments are importantly influenced by the likelihood of a beneficial outcome. Commonly used prognostic models have not been calibrated for use in the very elderly. Furthermore, they do not address long-term survival and functional outcome.ConclusionWe advocate the development of new prognostic models, validated in elderly ICU patients, that predict not only survival but also functional and cognitive status after discharge. Such a model may support informed decision making with respect to patients' preferences.

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