• Anaesthesia · Apr 1987

    The loading dose for continuous infusion epidural analgesia. A technique to reduce the incidence of hypotension.

    • D M MacLeod, H K Tey, G F Byers, W C Dollery, and M E Tunstall.
    • Anaesthesia. 1987 Apr 1; 42 (4): 377-81.

    AbstractThe effects of 0.08% and 0.5% bupivacaine, given in equal volumes as the loading dose prior to continuous infusion epidural analgesia, were compared. The incidence of hypotension, as well as the height of sensory blockade, was markedly lowered by reducing the loading dose of bupivacaine. However, the efficacy of the epidural analgesia was maintained by using the same volume for the loading dose. The mean onset of analgesia was delayed from 9.1 to 13.6 minutes. There were fewer calls for intervention consequent upon the reduction in adverse effects. The use of 8 ml 0.08% bupivacaine for the loading dose or for subsequent top-ups is recommended. The concept of a liquid sleeve of local anaesthetic in the epidural space is further supported.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…