• Clin. Infect. Dis. · Oct 2015

    A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis.

    • Mark Patrick Nicol, Devasena Gnanashanmugam, Renee Browning, Eleanor S Click, Luis E Cuevas, Anne Detjen, Steve M Graham, Michael Levin, Mamodikoe Makhene, Payam Nahid, Carlos M Perez-Velez, Klaus Reither, Rinn Song, Hans M L Spiegel, Carol Worrell, Heather J Zar, and Gerhard Walzl.
    • Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service of South Africa.
    • Clin. Infect. Dis. 2015 Oct 15; 61Suppl 3: S164-72.

    AbstractChildhood tuberculosis contributes significantly to the global tuberculosis disease burden but remains challenging to diagnose due to inadequate methods of pathogen detection in paucibacillary pediatric samples and lack of a child-specific host biomarker to identify disease. Accurately diagnosing tuberculosis in children is required to improve case detection, surveillance, healthcare delivery, and effective advocacy. In May 2014, the National Institutes of Health convened a workshop including researchers in the field to delineate priorities to address this research gap. This blueprint describes the consensus from the workshop, identifies critical research steps to advance this field, and aims to catalyze efforts toward harmonization and collaboration in this area. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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