• Int J Technol Assess Health Care · Jan 1998

    Randomized Controlled Trial Multicenter Study Clinical Trial

    Economic analysis of tirilazad mesylate for aneurysmal subarachnoid hemorrhage. Economic evaluation of a phase III clinical trial in Europe and Australia.

    • H Glick, R Willke, D Polsky, T Llana, W M Alves, N Kassell, and K Schulman.
    • University of Pennsylvania, USA.
    • Int J Technol Assess Health Care. 1998 Jan 1; 14 (1): 145-60.

    AbstractThis study used data from a multinational phase III randomized, double-blind, vehicle-controlled trial to evaluate the cost-effectiveness of tirilazad mesylate (Freedox) in the treatment of aneurysmal subarachnoid hemorrhage. In men, therapy with 6 mg/kg per day of tirilazad mesylate was associated with significantly increased survival, increased cost of care, and ratios of cost per death averted that compare favorably with the ratios of other life and death interventions. In women, it appeared to have no effects on costs or survival. Further clinical studies may provide additional information about the cost-effectiveness of this intervention.

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