• Swiss medical weekly · Apr 1995

    Case Reports

    [Cerebral toxoplasmosis with central diabetes insipidus and panhypopituitarism in a patient with AIDS].

    • M Brändle, P L Vernazza, M Oesterle, and R L Galeazzi.
    • Medizinische Klinik A, Kantonsspital St. Gallen.
    • Swiss Med Wkly. 1995 Apr 8; 125 (14): 684-7.

    AbstractEndocrine disorders in the course of HIV infection are often a result of opportunistic infections of endocrine organs. We describe the case of a 30-year-old HIV positive man in whom diabetes insipidus developed initially with no abnormal findings in cranial magnetic resonance imaging. 2 months later the patient presented with symptoms of panhypopituitarism. At this time, neuroradiologic examination was consistent with cerebral toxoplasmosis. Symptoms and neuroradiologic findings improved after treatment for cerebral toxoplasmosis. Toxoplasmosis is the most frequent opportunistic infection of the brain in patients with AIDS. In HIV positive patients with malfunction of the hypothalamic-hypophyseal system cerebral toxoplasmosis must be considered in differential diagnosis. Treatment of this disorder may alleviate symptoms and signs of endocrine malfunction.

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