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Br J Oral Maxillofac Surg · Oct 1999
Randomized Controlled Trial Comparative Study Clinical TrialUse of intra-articular morphine for postoperative analgesia following TMJ arthroscopy.
- C J Bryant, S D Harrison, C Hopper, and M Harris.
- Department of Oral and Maxillofacial Surgery, Eastman Dental and University College Hospitals, London, UK.
- Br J Oral Maxillofac Surg. 1999 Oct 1; 37 (5): 391-6.
AbstractRecent studies have suggested that giving opioids locally into inflamed tissue may cause analgesia. This antinociceptive effect has been attributed to the interaction of the drug with opioid receptors upregulated by inflammation in the peripheral tissues. We have compared the analgesic effect of intra-articular morphine with that of normal saline and a combination of morphine and its antagonist naloxone after arthroscopy of the temporomandibular joint (TMJ). Twenty-one patients took part in a randomized controlled double-blind trial and received one of these three solutions at the end of operation. The pain scores, time to the first request for analgesia, and the analgesic consumption of the patients in the three groups did not differ significantly at any time during the study period.
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