• Neural Regen Res · Apr 2012

    Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits.

    • Xiaodong Wei, Xing Wan, Bo Zhao, Jiabao Hou, Min Liu, and Bangchang Cheng.
    • Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
    • Neural Regen Res. 2012 Apr 15; 7 (11): 837-41.

    AbstractThe present study established a rabbit model of global cerebral ischemia using the 'six-vessel' method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared. Results revealed that propofol inhibited serum interleukin-8, endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion. In addition, cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment. The cross-sectional area of neuronal nuclei was, however, increased following propofol treatment. These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury.

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