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Curr Pain Headache Rep · Jun 2004
ReviewStrategies for finding new pharmacological targets for neuropathic pain.
- Marshal Devor.
- Institute of Life Sciences and Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel. marshlu@vms.huji.ac.il
- Curr Pain Headache Rep. 2004 Jun 1; 8 (3): 187-91.
AbstractChronic pain of neuropathic origin is an unmet therapeutic challenge that may require the development of novel drug entities. The resources involved in developing novel drugs and testing them in clinical trials are so large that few candidates can be fully tested in practice. A poor choice can have major repercussions. At the same time, the research community has identified large numbers of potential pharmacological targets for analgesia in recent years, with individual investigators promoting favorites with increasing zeal. Because of the uncertain predictive value of animal models of neuropathic pain, it is essential to consider rational strategic approaches to selecting the most likely candidate targets.
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