• Biomarkers · Mar 2015

    Comparative Study

    Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.

    • Hector R Wong, Keith R Walley, Ville Pettilä, Nuala J Meyer, James A Russell, Sari Karlsson, Michael G S Shashaty, and Christopher J Lindsell.
    • Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Hospital Research Foundation , Cincinnati, OH , USA .
    • Biomarkers. 2015 Mar 1; 20 (2): 132-5.

    ContextWe recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk.ObjectiveThe objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT).MethodsThe area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235).ResultsThe area under the curve for ASSIST was greater than that of IL6 and PCT.ConclusionsASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…