• Am J Hosp Palliat Care · Feb 2010

    The use of transdermal fentanyl in cancer pain--a compliance study of outpatients in Taiwan.

    • Tzeon-Jye Chiou, Chun-Yu Liu, Woan-Fang Tzeng, Yu-Chieh Su, Yih-Chyang Weng, Chih-Jen Hung, Yeh Tang, Yu-Jen Chen, and Taiwan Cancer Pain Study Group.
    • Department of Medicine, Division of Transfusion Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan. tjchiou@vghtpe.gov.tw
    • Am J Hosp Palliat Care. 2010 Feb 1; 27 (1): 31-7.

    AbstractThe aim of this study is to investigate cancer patients' response and side effects associated with transdermal therapeutic fentanyl (TTS-F), whose pain was hardly controlled by nonweak/weak opioids in Taiwan. From 2005 to 2006, 822 outpatients received TTS-F to collect pain assessment forms and diaries for 4 weeks. Most (78.7%) patients were initially prescribed 25 microg/h TTS-F. Doses were adjusted weekly at clinicians' discretion, according to pain assessment and side effects. Patients receiving 50 microg/h, 75 microg/h, and > 75 microg/h TTS-F had increased from 17.5% to 32.1%, 1.8% to 3.4%, and 1.9% to 2.2%, respectively, by week 2; further small increases were found in weeks 3 and 4. Pain palliation improved from 60.6% during week 1 to 78.6% at week 4. The common adverse effects were nausea/vomiting. Patient's compliance was >90%. This study found that the TTS-F is effective and well tolerated.

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