• Clin. Appl. Thromb. Hemost. · Sep 2012

    Randomized Controlled Trial

    A randomized controlled trial on the hemostasis of femoral artery using topical hemostatic agent.

    • Soheila S Kordestani, Fereidoon Noohi, Hossein Azarnik, Hossein Basiri, M J Hashemi, S Abdi, A Mohebi, M Madani, and Farzaneh Nayebhabib.
    • Department of Biomedical Engineering, Amir Kabir University of Technology, Tehran, Islamic Republic of Iran. ss.kordestani@chitotech.com
    • Clin. Appl. Thromb. Hemost. 2012 Sep 1; 18 (5): 501-5.

    ObjectiveEvaluation of the effect of using a topical hemostatic agent named "ChitoHem(®)" on different factors on patients undergoing diagnostic coronary angiography.MethodsThe present blind, randomized, controlled study included 124 patients randomly divided into 2 groups. In the treatment group following femoral sheath removal, ChitoHem(®) powder and in the control group conventional hemostatic procedure was applied.ResultsIn the treatment group, time to hemostasis, ambulation, and the use of sandbag were significantly shorter compared with the control group, respectively (4.6 ± 1.3 vs 12.4 ± 4.4 minutes, 3.5 ± 2.7 vs 23.0 ± 1.73 hours and 1.6 vs 98.4%; P < .05). There were no significant differences in hematoma formation and re-bleeding between the 2 groups.ConclusionIt was exhibited ChitoHem(®) topical hemostatic powder used on treatment patients undergoing diagnostic coronary angiography was statistically superior at reducing the time to hemostasis and ambulation as well as the use of sandbags compared with manual compression in control group.

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