• Journal of nephrology · Sep 2011

    Review

    Do HMG-CoA reductase inhibitors improve kidney function? The saga continues.

    • Vito M Campese, Elaine Ku, Roberto Bigazzi, and Stefano Bianchi.
    • Division of Nephrology, Keck School of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA. campese@usc.edu
    • J. Nephrol. 2011 Sep 1; 24 (5): 550-3.

    AbstractSeveral reviews have addressed the role of dyslipidemia in renal injury and the potential renal protective effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins). Experimental evidence in animals strongly supports the concept that statins may be renal protective. However, data in humans are scanty and contradictory. A recent controlled study using rosuvastatin has cast some doubts on the renal protective effect of this drug. This article reviews the available evidence pro and con the renal protective effects of statins in human subjects.

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