• Pediatr Hematol Oncol · Sep 2009

    Procalcitonin and C-reactive protein serum levels as markers of infection in a pediatric population with febrile neutropenia and cancer.

    • Manuel Martinez-Albarran, Jose de Jesus Perez-Molina, Sergio Gallegos-Castorena, Fernando Sanchez-Zubieta, Susana Del Toro-Arreola, Rogelio Troyo-Sanroman, and Oscar Gonzalez-Ramella.
    • Departamento de Hematologia y Oncologia Pediatrica, Hospital Civil de Guadalajara Juan I. Menchaca, Guadalajara, Jalisco, Mexico.
    • Pediatr Hematol Oncol. 2009 Sep 1; 26 (6): 414-25.

    BackgroundProcalcitonin and C-reactive-protein are inflammatory markers for sepsis. The authors evaluated their sensitivity and specificity in pediatric patients with cancer and febrile neutropenia.ProcedureSerum procalcitonin and C-reactive-protein were evaluated. Patients (n = 54) were divided into 2 groups, with severe infection (n = 18) or without documented infection (n = 36).ResultsProcalcitonin and C-reactive protein were significantly higher in the high-risk group. Procalcitonin displayed 72.2% sensitivity and 80.5% specificity. C-reactive-protein had a sensitivity of 77.7% and specificity of 77.2%.ConclusionsProcalcitonin is an accurate predictor of bacterial infection in neutropenic children, while C-reactive-protein may be a better screening test in emergency settings.

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