• Infection · Nov 1996

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections.

    • P Kempf, A Bauernfeind, A Müller, and J Blum.
    • Chirurgische Klinik, Stadtkrankenhaus Rüsselsheim, Germany.
    • Infection. 1996 Nov 1; 24 (6): 473-9.

    AbstractIn an open, randomised, multicentre trial, the efficacy and tolerability of empirical meropenem monotherapy (1 g intravenously every 8 hours) and cefotaxime (2 g every 8 hours) plus metronidazole (0.5 g intravenously every 8 hours) for 5 to 10 days was compared in 94 patients with serious intra-abdominal infection who required surgery. Eighty-three patients had an evaluable clinical response. Significantly more patients in the meropenem group had a satisfactory clinical response at the end of treatment (41/43 [95.3%] vs 30/40 [75.0%]; p = 0.008). The bacteriological response was also higher in the meropenem group (31/33 vs 26/32). In the bacteriologically evaluable population, a satisfactory clinical response was observed in 31/33 of those who received meropenem compared to 24/32 of the cefotaxime/metronidazole recipients (p = 0.03). Empirical meropenem monotherapy should prove a useful alternative to the currently standard combination treatment for serious intraabdominal infections.

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