• Nitric Oxide · Dec 2000

    Review

    Nitric oxide synthase-independent generation of nitric oxide in muscle ischemia--reperfusion injury.

    • D A Lepore.
    • Bernard O'Brien Institute of Microsurgery, St. Vincent's Hospital, Fitzroy, 3065, Melbourne, Australia. d.lepore@surgerysvh.unimelb.edu.au
    • Nitric Oxide. 2000 Dec 1; 4 (6): 541-5.

    AbstractNitric oxide (NO) is an important molecule in many physiological or pathophysiological processes including ischemia--reperfusion injury. The enzymatic nitric oxide synthase (NOS)-dependent pathway was universally accepted as the source of NO in ischemia-reperfusion injury. However, generation of NO that is independent of NOS has also been identified in ischemia--reperfusion injury to both cardiac and skeletal muscle. This review summarizes the evidence for the generation NOS-independent NO in ischemia--reperfusion injury to cardiac and skeletal muscle.Copyright 2000 Academic Press.

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