• Pharmacol Rep · Jan 2005

    Randomized Controlled Trial Clinical Trial

    Effects of thiopental and propofol on heart rate variability during fentanyl-based induction of general anesthesia.

    • Lesya Riznyk, Magdalena Fijałkowska, and Krzysztof Przesmycki.
    • II Department of Anaesthesiology and Intensive Care, F. Skubiszewski Medical University, Staszica 16, PL 20-081 Lublin, Poland. anest2@am.lublin.pl.
    • Pharmacol Rep. 2005 Jan 1; 57 (1): 128-34.

    AbstractAnesthetics depress the autonomic nervous system. The effects of thiopental and propofol on heart rate variability (HRV) during fentanyl-based induction of general anesthesia were studied in one hundred patients. We observed different effects of fentanyl, thiopental and propofol on HRV. Fentanyl decreased total power of HRV and low frequency power (LF), but not high frequency power (HF), indicating a greater reduction of cardiac sympathetic activity. Thiopental and propofol caused the further reduction of HRV and decreased HF power. Thiopental increased LF power and LF/HF ratio, indicating that the vagolytic effect is associated with the increase in sympathetic activity. Propofol preserved the LF power, indicating that the cardiac parasympathetic activity is reduced more than the sympathetic activity.

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