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Neuroscience letters · Feb 2009
Amyloid beta concentrations in older people with Down syndrome and dementia.
- Emma L Jones, Marisa Hanney, Paul T Francis, and Clive G Ballard.
- Wolfson Centre for Age-related Disease, Wolfson CARD, Guy's Campus, King's College London, London SE1 1UL, United Kingdom. emma.3.jones@kcl.ac.uk <emma.3.jones@kcl.ac.uk>
- Neurosci. Lett. 2009 Feb 20; 451 (2): 162-4.
AbstractPeople with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon Abeta1-40 or Abeta1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population.
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