• Ilker Ince, Ozgur Yoruk, Ali Ahiskalioglu, Mehmet Aksoy, Aysenur Dostbil, and Mine Celik.
• Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey ilkerince1983@yahoo.com.
• Otolaryngol Head Neck Surg. 2015 Aug 1; 153 (2): 269-74.

ObjectiveTonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids. Pain control is still a big problem after tonsillectomy surgery. We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post-tonsillectomy pain management. This is the first-time use of montelukast in post-tonsillectomy pain.Study DesignDouble-blind, controlled-randomized study.SettingsUniversity teaching and research hospital.Subjects And MethodsA total of 60 children, aged 5 to 15 years, American Society of Anesthesiologist class I-II, scheduled for elective tonsillectomy were enrolled in this clinical trial study. The patients were randomized into 2 groups: the montelukast group (group M, n = 30) and control group (group C, n = 30). Group M recieved an oral montelukast tablet and group C recieved placebo at 2400pm on the morning before surgery. Post-tonsillectomy pain was evaluated with the Wong-Baker FACES Scale during the 24 hours after surgery. Patients' intraoperative hemodynamic parameters and intraoperative and postoperative complications were recorded.ResultsThere were statistically significant differences between group C and group M for Wong-Baker FACES pain rating scale scores (P < .05). In the 24 hours after surgery, the total number of patients using rescue analgesics was higher in group C than in group M, and the difference was statistically significant (P < .001). There was no significant difference in demographic parameters (P > .05). There were no significant differences in postoperative nausea and vomiting, otalgia, trismus, fever, or halitosis between the groups (P > .05).ConclusionPreemptive montelukast can be used safely to reduce the serious pain caused by tonsillectomy in children.© American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

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