• J Minim Invasive Gynecol · Mar 2016

    Randomized Controlled Trial Comparative Study

    The Effects of Volume-Controlled and Pressure-Controlled Ventilation on Lung Mechanics, Oxidative Stress, and Recovery in Gynecologic Laparoscopic Surgery.

    • Chia-Chih Liao, Yi-Chuan Kau, Pei-Chi Ting, Shih-Chang Tsai, and Chin-Jung Wang.
    • Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kwei-Shan, Taoyuan, Taiwan.
    • J Minim Invasive Gynecol. 2016 Mar 1; 23 (3): 410-7.

    Study ObjectiveTo compare ventilation variables, changes in oxidative stress, and the quality of recovery in 2 different ventilation strategies (volume-controlled ventilation [VCV] and pressure-controlled ventilation [PCV]) during gynecologic laparoscopic surgery.DesignA prospective randomized controlled trial (Canadian Task Force classification I).SettingOne university teaching hospital in Taiwan.PatientsWomen scheduled for laparoscopic gynecologic surgery.InterventionsWomen were randomly assigned to receive either VCV or PCV during surgery.Measurements And Main ResultsVentilation variables were recorded 1 minute before and 1 hour after pneumoperitoneum. Blood samples were collected for malondialdehyde measurement at 7 points: 1 minute before and 1 hour after pneumoperitoneum; 30, 60, 90, and 120 minutes after deflation; and 24 hours after surgery. Postoperative recovery was assessed by using a 9-item quality of recovery score at 24 hours after surgery. A total of 52 women randomly allocated to the VCV (n = 27) or PCV (n = 25) group completed the study. We found that after 1 hour of insufflation the PCV group had lower peak airway pressure (22.0 ± 3.4 vs 26.6 ± 4.1 cm H2O, p < .0001) and higher compliance (28.4 ± 3.7 vs 24.1 ± 3.3 mL/cm H2O, p < .0001) than the VCV group. In plasma levels of malondialdehyde, there were no significant differences between the 2 groups at 7 time points. The levels significantly increased in both groups after 1 hour of pneumoperitoneum and peaked at 2 hours after deflation. During postoperative recovery, lower scores were obtained at 24 hours after surgery compared with preoperative scores, but there were no significant differences between the 2 groups.ConclusionPCV is an alternative ventilation mode in gynecologic laparoscopic surgery. However, PCV offered lower peak airway pressure and higher compliance than VCV but no advantages over VCV in oxidative stress or quality of recovery.Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.

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