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Eur J Cardiothorac Surg · Apr 1997
Letter Randomized Controlled Trial Comparative Study Clinical TrialThe use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations.
- R W Landymore, J T Murphy, H Lummis, and C Carter.
- Eur J Cardiothorac Surg. 1997 Apr 1; 11 (4): 798-800.
AbstractPatients undergoing primary myocardial revascularization were randomized to one of three drug regimens (low-dose aprotinin, epsilon-aminocaproic Acid or tranexamic Acid) to determine which drug regimen would most effectively reduce post-operative bleeding and the need for blood products. All patients had received 325 mg of aspirin within 48 h before operation. All three drug regimens reduced the requirements for blood products and postoperative bleeding after coronary artery bypass operations. There was, however, no significant difference between drug regimens.
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