-
- P C Darimont and L C Jenkins.
- Can Anaesth Soc J. 1977 Jan 1; 24 (1): 42-56.
AbstractThis study assesses the effects of agents commonly used in anaesthesia on enflurane-induced seizure threshold and on established seizure activity, during steady state enflurane anaesthesia. EEG seizure activity was monitored in cats from chronic cortical and subcortical recording sites. Diazepam, thiopentone, methohexitone and ketamine all enhanced established EEG seizure challenge. This latter effect was most evident under conditions of lowered PaCO2. The effects of these intravenous agents on established enflurane seizure patterns exceeded in duration the expected EEG effect of the agent when used alone. The limited number of experiments, however, precluded statistical verification of our findings. The similarities between centrencephalic minor motor seizures and enflurane seizure pattern in terms of EEG and convulsive expression, including drug response, are noted.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..