• Trends in neurosciences · Oct 2001

    Review

    Do active cerebral neurons really use lactate rather than glucose?

    • C P Chih, P Lipton, and E L Roberts.
    • Geriatric Research, Education, and Clinical Center, and Research Office, Miami VA Medical Center, Miami, FL 33125, USA.
    • Trends Neurosci. 2001 Oct 1; 24 (10): 573-8.

    AbstractGlucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by anaerobic glycolysis, whereas neuronal metabolism is fueled by lactate released from glia. In this article, we critically examine the evidence supporting this hypothesis and explain, from the perspective of enzyme kinetics and substrate availability, why neurons probably use ambient glucose, and not glial-derived lactate, as the major substrate during activity.

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