• Acta Obstet Gynecol Scand · Aug 2010

    Randomized Controlled Trial

    Efficacy of intrauterine lignocaine plus vaginal misoprostol for pain relief in premenopausal women undergoing endometrial aspiration and ambulatory hysteroscopy.

    • Nupur Gupta, Bindiya Gupta, Vatsla Dadhwal, and Suneeta Mittal.
    • Department of Obstetrics & Gynaecology, Sukhda Hospital, New Delhi, India. nupurkothari2000@yahoo.com
    • Acta Obstet Gynecol Scand. 2010 Aug 1; 89 (8): 1066-70.

    ObjectiveTo compare the effectiveness of a combination of intrauterine lignocaine and vaginal misoprostol in reducing pain at hysteroscopy and endometrial aspiration (EA).DesignProspective randomized trial (Canadian Task Force Classification I).SettingTertiary care referral hospital.PopulationForty-nine premenopausal women undergoing hysteroscopy plus EA.MethodsPatients were randomized into misoprostol plus intrauterine lignocaine group (Group I) and only misoprostol group (Group II).Main Outcome MeasuresPain scores at hysteroscope insertion (T (time) 1), during and after hysteroscopy (T2, T3), during EA (T4), 15 minutes after the procedure (T5) and at discharge (T6). Satisfaction and procedure acceptability was assessed by a questionnaire.ResultsThe mean age of patients in Group I and Group II was 35.4 +/- 8.6 years and 38.9 +/- 13.2 years, respectively. The mean pain scores in Group I were 23.6% lower at T2 and 27% lower at T4 when compared with Group II; the difference of latter being significant.ConclusionA combination of intrauterine lignocaine plus vaginal misoprostol reduced the pain score in premenopausal women undergoing hysteroscopy and EA.

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