• N A Osipova, V A Beresnev, M S Vetsheva, and T V Dolgopolova.
• Anesteziol Reanimatol. 1999 Nov 1 (6): 71-4.

AbstractA prophylactic approach to the management of postoperative pain is described: ketoprofen, a nonsteroid antiinflammatory drug, was used, which possesses numerous advantages and a variety of dosage forms. To cancer patients subjected to extensive radical operations on the pelvic organs, head, and neck, ketonal (ketoprofen) was injected intramuscularly or rectally in a dose of 100 mg 1 h before surgery and in a daily dose of 300 mg during the postoperative period. Adequate postoperative monoanalgesia with ketonal was attained in 47% patients. In the rest patients ketonal was combined with medium-potent opioid tramadol. A more potent opioid buprenorfin (sangesik) in the minimal daily dose of 0.3 mg was required in only 2 cases. Nonsteroid antiinflammatory drug ketoprofen (ketonal) in therapeutic doses administered preventively before surgery intramuscularly or rectally notably decreased the acuity of the postoperative pain syndrome.

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