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Psychiatry research · Jul 2012
No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students.
- Changgui Kou, Xiangfei Meng, Bing Xie, Jieping Shi, Qiong Yu, Yaqin Yu, and Carl D'Arcy.
- Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
- Psychiatry Res. 2012 Jul 30; 198 (2): 313-5.
AbstractThis study investigates the genetic association between catechol-O-methyltransferase (COMT) gene polymorphisms and neurotic disorders. Data were derived from a case-control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag single nucleotide polymorphisms (SNPs) on the COMT gene were tested using polymerase chain reaction (PCR)-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on the COMT gene assessed were not associated with neurotic disorders. Our finding suggests that the COMT gene may not be a susceptibility gene for neurotic disorders.Copyright © 2012 Elsevier Ltd. All rights reserved.
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