• Hidenori Ichiyasu, Yuko Horio, Shinsuke Tsumura, Susumu Hirosako, Yasumiko Sakamoto, Shinya Sakata, Kei Nakashima, Taiyo Komatsu, Keisuke Kojima, Aiko Masunaga, Kazuhiko Fujii, Naoki Saita, and Hirotsugu Kohrogi.
• Department of Respiratory Medicine, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University , Kumamoto , Japan.
• Mod Rheumatol. 2014 Mar 1; 24 (2): 361-5.

AbstractWe present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated with two courses of direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment with high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease and hypoxemia deteriorated in all the patients. After PMX-DHP treatment, the PaO2/FiO2 ratio and serum LDH and KL-6 were improved, the abnormal shadows in chest high-resolution computed tomography (HRCT) scans gradually decreased, and, finally, all patients survived. These findings indicate that PMX-DHP treatment could be effective in the management of RPIP in patients with C-ADM in combination with conventional therapy.

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