• Marcelo Minharro Ceccheti, Giovana Vigário Negrato, Maria Paula Siqueira de Melo Peres, Maria Cristina Zindel Deboni, and Maria da Graça Naclério-Homem.
• Oral and Maxillofacial Surgery Department, General Clinics Hospital School of Medicine, University of Sao Paulo, São Paulo, Brazil.
• Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Mar 1; 117 (3): e249-54.

ObjectiveThe aim of this study was to assess analgesic and adjuvant anesthetic effects of submucosal tramadol after third molar extraction.Study DesignIn this double-blind, split-mouth, placebo-controlled, single-dose, crossover investigation, 52 patients underwent mandibular third molar extraction under local anesthesia. Surgical side was randomly assigned to submucosal 2 mL 100 mg tramadol injection (group T) or normal saline solution (group P) immediately after surgery. Anesthetic blockade duration, time of intake and amount of analgesic rescue drug, and postoperative pain intensity were recorded immediately after anesthesia cessation and 4, 8, 24, 48, and 72 hours after surgery. Data were submitted to analysis of variance and Wilcoxon tests.ResultsAnesthetic blockade duration between groups was similar. Group T took significantly less rescue drug after 72 hours (P = .008). Time elapsed before first intake of rescue drug was longer (P = .006), and pain intensity was significantly lower (P = .001) in group T.ConclusionsSubmucosal tramadol injection after oral surgery improved postoperative analgesia, but did not extend anesthetic action duration.Copyright © 2014 Elsevier Inc. All rights reserved.

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