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Randomized Controlled Trial Clinical Trial
Propofol and fentanyl act additively for induction of anaesthesia.
- I Ben-Shlomo, J Finger, E Bar-Av, A Z Perl, A Etchin, and M Tverskoy.
- Department of Anaesthesia, Rebecca Sieff Hospital, Safed, Israel.
- Anaesthesia. 1993 Feb 1; 48 (2): 111-3.
AbstractThe induction dose-response of propofol was compared with the dose-response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose-response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty-three percent of the ED50 of fentanyl was required in combination with 75% of the ED50 for propofol to achieve the ED50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.
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