• A Di Filippo, F Marini, M Pacenti, S Dugheri, L Focardi, and G P Novelli.
• Department of Medical and Surgical Critical Care, University of Florence, Italy. aledanibatibeba@hotmail.com
• Acta Anaesthesiol Scand. 2002 Sep 1; 46 (8): 1017-20.

BackgroundTo define the best strategy to reduce Compound A production in Sevoflurane low-flow anaesthesia by experiments in vitro and in vivo of different absorbers and different anaesthesia machines.MethodsIn vitro Compound A has been measured at 45 degrees C in vitro following Sevoflurane interactions with potassium hydroxide, sodium hydroxide, soda lime, Dragersorb 800 Plus and Amsorb, a new absorber that does not contain sodium or potassium hydroxide. In vivo Compound A concentration in the anaesthesia circuit (inspiratory branch) has been measured using an indirect sampling method through absorber vials (SKC) with active coal granules, during low flows (500 ml/min) general anaesthesia using soda lime, Dragersorb 800 Plus or Amsorb as absorber. Compound A was also measured during low flows (500 ml/min) general anaesthesia using as carbon dioxide absorber soda lime with different anaesthesia machines.ResultsIn vitro at 45 degrees C Compound A concentration with soda lime and Dragersorb 800 Plus was about 10 times higher than with Amsorb. In vivo the Compound A concentrations in the inspiratory branch of the circuit were lower in the group with Amsorb.ConclusionThe Compound A production is minimal with Amsorb as carbon dioxide absorber.

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