• Astrid Kerker, Christian Hardt, Hans-Eugen Schlief, and Franz Ludwig Dumoulin.
• Department of Medicine, Gemeinschaftskrankenhaus Bonn, Bonner Talweg 4-6, D-53113 Bonn, Germany.
• Bmc Gastroenterol. 2010 Jan 1; 10: 11.

BackgroundAlthough gastrointestinal endoscopy with sedation is increasingly performed in elderly patients, data on combined sedation with midazolam/propofol are very limited for this age group.MethodsWe retrospectively analyzed 454 endoscopic procedures in 347 hospitalized patients >or= 70 years who had received combined sedation with midazolam/propofol. 513 endoscopic procedures in 397 hospitalized patients < 70 years during the observation period served as controls. Characteristics of endoscopic procedures, co-morbidity, complications and mortality were compared.ResultsElderly patients had a higher level of co-morbidity and needed lower mean propofol doses for sedation. We observed no major complication and no difference in the number of minor complications. The procedure-associated mortality was 0%; the 28-day mortality was significantly higher in the elderly (2.9% vs. 1.0%).ConclusionsIn this study on elderly patients with high level co-morbidity, a favourable safety profile was observed for a combined sedation with midazolam/propofol with a higher sensitivity to propofol in the elderly.

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