• Clin. Pharmacol. Ther. · Oct 2015

    Review

    Oseltamivir for the treatment of H1N1 influenza during pregnancy.

    • R H Beigi, V C Pillai, R Venkataramanan, and S N Caritis.
    • Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
    • Clin. Pharmacol. Ther. 2015 Oct 1; 98 (4): 403-5.

    AbstractPregnancy heightens the risk of adverse outcomes from influenza infections. This is true for both seasonal epidemics as well as occasional pandemics. Seasonal influenza vaccines are the focus of disease prevention and are recommended for all pregnant women in any trimester of pregnancy and postpartum. Oseltamivir (Tamiflu) is currently the recommended and most commonly used pharmaceutical agent for influenza prophylaxis and treatment. Oseltamivir has been demonstrated to prevent disease after exposure, treat infected individuals, as well as lessen the likelihood of complications. The physiologic adaptations of pregnancy alter the pharmacokinetics of this important drug. Evidence of these alterations, knowledge gaps, and future investigative directions to fill these knowledge gaps are highlighted.© 2015 The American Society for Clinical Pharmacology and Therapeutics.

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