• Martine C M Willems, Thijs Hendriks, Ben M de Man, Roger M L M Lomme, and J Adam van der Vliet.
• Division of Vascular and Transplant Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. mwillems@flevoziekenhuis.nl
• Wound Repair Regen. 2011 Nov 1; 19 (6): 680-6.

AbstractThe use of mammalian target of rapamycin inhibitors coincides with an increased incidence of surgical complications. In previous experiments, serious negative effects of postoperative everolimus on anastomotic strength were found. This study aims to investigate if delayed drug administration can prevent loss of wound strength. Ten groups of Wistar rats each received daily oral doses of 1.0 or 2.0 mg/kg everolimus, starting the day of anastomotic construction in both ileum and colon, or 1, 2, 3, or 4 days later. The 11th group received saline. Seven days later, wound strength in anastomoses and in the abdominal wall and wound hydroxyproline levels were measured. Mean wound strength was significantly and dose-dependently reduced if everolimus was started on the day of operation. In ileum and colon, strength was not affected if drug administration was delayed until the third or second day, respectively. In abdominal fascia, this was the case only if everolimus was withheld until day 4. In general, changes in wound hydroxyproline content showed similarities to changes in wound strength. Thus, delaying administration of everolimus for 2-4 days after operation can prevent a serious loss of wound strength, both in the intestine and in the abdominal fascia.2011 by the Wound Healing Society.

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