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- Mónica Troncoso Sch, Carla Rojas H, and Eduardo Bravo C.
- Servicio de Neuropsiquiatría Infantil, Hospital Clínico San Borja, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
- Rev Med Chil. 2008 Jun 1; 136 (6): 763-6.
AbstractRetinoic acid is a widely used drug in the treatment of cystic acne. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months old female whose mother was exposed to retinoic acid in both pre-gestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms of the teratogenic effects of retinoic acid.
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