• Biol. Pharm. Bull. · Mar 2008

    Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain.

    • Tsugunobu Andoh, Kenji Sugiyama, Masahide Fujita, Yuko Iida, Hiroshi Nojima, Ikuo Saiki, and Yasushi Kuraishi.
    • Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
    • Biol. Pharm. Bull. 2008 Mar 1; 31 (3): 520-2.

    AbstractUsing a mouse model of advanced skin cancer which has mixed nociceptive-neuropathic pain, we evaluated the analgesic effects of morphine and analgesic adjuvants. Morphine hydrochloride (10--30 mg/kg, oral) and mexiletine hydrochloride (10--30 mg/kg, intraperitoneal) dose-dependently inhibited thermal hyperalgesia. Baclofen (10 mg/kg, subcutaneous) suppressed thermal hyperalgesia, without effects at lower doses of 1 and 5 mg/kg. Ketamine hydrochloride (50 mg/kg, oral) was without effect. Analgesic tolerance was observed after 6th administration of morphine, and it was not developed until at least 7th administration of mexiletine and baclofen. This mouse model of skin cancer may be useful for the pharmacological evaluation of the effects of opioids and analgesic adjuvants on mixed nociceptive-neuropathic pain of advanced cancer.

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