• Filippo Sanfilippo, Federica Chiarenza, Cesare Cassisi, Cristina Santonocito, Theodoros Tsoutsouras, Marialena Trivella, Stephen Gerry, Marinella Astuto, Shane George, and David P Taggart.
• Cardiothoracic Intensive Care Unit, Oxford Heart Centre, John Radcliffe Hospital-Oxford University Hospitals, Oxford, United Kingdom; School of Anaesthesia and Intensive Care, University of Catania, Catania, Italy. Electronic address: filipposanfi@yahoo.it.
• J. Cardiothorac. Vasc. Anesth. 2016 Aug 1; 30 (4): 909916909-16.

ObjectiveHyperlactatemia and base deficit (BD) are markers of adverse outcome after cardiac surgery, and their derangement can be influenced by the use of extracorporeal circulation. The authors hypothesized a better postoperative metabolic profile in off-pump coronary artery bypass grafting (OPCABG) compared with "on-pump" coronary artery bypass grafting (ONCABG).DesignThis was a retrospective study, with consecutive data collected for 1 year from electronic medical records.SettingCardiothoracic intensive care unit at a tertiary university hospital.ParticipantsThe study comprised 339 patients who underwent elective coronary artery bypass grafting (ONCABG [n = 215], OPCABG [n = 124]).InterventionsNone.Measurements And Main ResultsThe metabolic (arterial lactatemia, pH, and BD) and hemodynamic (inotropic/vasopressor support) parameters of OPCABG and ONCABG patients were compared at 7 predefined time points (intensive care admission and the 1st, 3rd, 6th, 12th, 18th, and 24th postoperative hours). For each output of interest, mixed-effects linear regression models were used (with time as random-effect to allow for clustering of repeated measures) and adjusted for a predetermined set of covariates. Arterial lactatemia and pH were comparable at all time points; BD was worse in the ONCABG group overall (p = 0.01) and at most time points (except at the 1st and 24th postoperative hours). For the whole period, inotropic support was more common in ONCABG patients (p<0.05), whereas vasopressor use was more frequent in the OPCABG group (p< 0.05).ConclusionsImproved postoperative BD values were demonstrated in the OPCABG group, although pH and lactatemia were similar between groups. Inotropic support was less common in the OPCABG group at the expense of more frequent vasopressor support.Copyright © 2016 Elsevier Inc. All rights reserved.

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